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Antibiotics and child mortality

March 2011
Amhara Region, EthiopiaWant to embed this video?
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When they studied child mortality, they found that in the villages that received azithromycin, the rates had been cut in half for children between the ages of one and five."
In these remote Ethiopian villages, scattered across a sweeping landscape with few roads, it’s difficult for health workers to make an impact.

Many of the villages are extremely poor, and living conditions are as basic as they get.

As a result, Ethiopia has one of the highest child mortality rates in the world.

Dr. Tom Lietman of the University of California, San Francisco, has been studying the area for some time. “The most common causes of deaths in children, in pre-school children, are the infectious diseases: they’re malaria, they’re respiratory disease, they’re diarrhea. As a matter of fact those three account for more than half the deaths in children.”

But two studies co-written by Lietman are raising hope.

There’s strong evidence that the antibiotic azithromycin has benefits far beyond its primary objective.

Azithromycin is taken orally to fight trachoma, an eye condition that is the leading cause of preventable blindness, affecting more than 40 million people worldwide.

The drug is given as part of a trachoma-control program administered by the Ethiopian government along with the Atlanta-based Carter Center and other partners.

Teshome Gebre, an Ethiopian working with The Carter Center, says, “This is a very strong antibiotic given once a year for those above five. The number of tablets is between two and four.”

Here in rural Ethiopia, trachoma is a common disease that can be detected by redness and painful scratching beneath the eyelid.

Dr. Paul Emerson, Director of The Carter Center’s Trachoma Control Program, says, “Children get infected with ocular chlamydia, which causes trachoma, at a very young age in this environment, probably months old. And they contract it from their elder brothers and sisters in the house.”

In the first study by the University of California team, people in some villages were treated with azithromycin, while others did not receive it until a year later.

Trachoma takes years to develop, so the delay was not considered a problem.

However, when they studied child mortality, they found that in the villages that received azithromycin, the rates had been cut in half for children between the age of one and five.

Dr. Lietman says, “The rates you’d expect in this area of Ethiopia may be eight or 10 deaths per thousand children per year, and we found eight and a half deaths per thousand children per year in the clinical trial, so exactly what we expected. Now the children who were in communities that were randomized through azithromycin distribution had about four deaths per thousand people per year. So it’s about half as much.”

A second study, conducted in other villages, and using a different technique, gave the same results.

It’s not clear why azithromycin had such a significant effect on child mortality in the studies, but the research showed that children were less likely to die of an infectious disease.

But even with these encouraging findings, some people in the global health community are opposed to mass distribution of antibiotics as a kind of ‘catch-all’.

They fear that over-use could lead to resistance to the antibiotics.

An alternative, or a strategy that could be used in conjunction with antibiotics, is a program to improve sanitation and in turn reduce fly and mosquito breeding grounds.

Efforts like this are well underway, promoting face-washing regimens and the construction of latrines.

But clean water and sanitation campaigns can be costly and difficult to implement, so research into widespread use of antibiotics will continue.

A three-year study is being planned for the West African nation of Niger involving 600-thousand people. That’s 10-times the size of the Ethiopia studies.

Researchers hope that effort will shed more light on the benefits – and any possible negative effects – of the use of antibiotics to save many young lives.
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